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4000-520-616
CASNumber520-36-5
EmpiricalFormula(HillNotation)C15H10O5
MolecularWeight270.24
BeilsteinRegistryNumber262620
ECNumber208-292-3
MDLnumberMFCD00006831
PubChemSubstanceID329747355
Itmaybeusedasinternalstandardfordeterminingpeurarinanditsmetabolites,usingLC-ESI-MS/MS,inbloodandurineofrats.
AplantflavonoidthathasbeenfoundtoinhibitcellproliferationbyarrestingthecellcycleattheG2/Mphase.Inhibitionofgrowththroughcellcyclearrestandinductionofapoptosisappeartoberelatedtoinductionofp53.InhibitsPMA-mediatedtumorpromotionbyinhibitingproteinkinaseCandtheresultingsuppressionofoncogeneexpression.IthasalsobeenreportedtoinhibittopoisomeraseI-catalyzedDNAre-ligationandenhancegapjunctionalintercellularcommunication.
Flavonoidsbelongtopolyphenolicclassofcompounds.TheyplaycrucialroleinBIOLOGicalactivitieswhichincludetumorgrowthinhibitionandchemoprevention.Apigeninisaplantflavonoidmostlyusedtoinhibitornithinedecarboxylaseactivityandskintumor.
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